Women of different status, profession, and principles become connected by association or circumstance.
Dr. Cleo Carrillo (Eula Valdez) is a famous dermatologist, whose roster of high-profile clients include beauty queen turned society empress Marilou Cobarrubias (Ruffa Gutierrez) and socialite Betchay Magbutay-Cavendish (Carmi Martin).
Cleo is married to a cardiologist, Dr. Vincent Carrillo. But her success comes with zealous detractors and nasty lawsuits, something which Marilou can relate to.
Marilou is widowed by her aged and ultra-rich husband, and her daughter-in-law, Amanda dela Vega, has arranged that she gets nothing except a small condo unit and a business on the verge of bankruptcy.